Organic Electrochemical Transistors functionalized with Protein Minibinders for Sensitive and Specific Detection of SARS‐CoV‐2

There is a need for rapid, sensitive, specific, and low-cost virus sensors. Recent work has demonstrated that organic electrochemical transistors (OECTs) can detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Here, simple approach to fabrication of OECT devices with excellent stability unprecedented sensitivity specificity detection SARS-CoV-2 demonstrated. The rely on engineered protein minibinder LCB1, which binds strongly SARS-CoV-2. resulting exhibit receptor binding domain (RBD). These results demonstrate simple, effective, biomolecular sensor applicable real-time general strategy device design be applied other pathogenic viruses.